Category Archives: pre-print

Pre-print: DNA polymerase β fingers movement revealed by single-molecule FRET suggests a partially closed conformation as a fidelity checkpoint

C. Fijen, M. Mahmoud, R. Kaup, J. Towle-Weicksel, J. Sweasy, and J. Hohlbein, bioRxiv, 2018 [link] The eukaryotic DNA polymerase β plays an important role in cellular DNA repair as it fills gaps in single nucleotide gapped DNA that result … Continue reading

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Pre-print: Substrate conformational dynamics drive structure-specific recognition of gapped DNA by DNA polymerase

T.D. Craggs, M. Sustarsic, A. Plochowietz, M. Mosayebi, H. Kaju, A. Cuthbert, J. Hohlbein, L. Domicevica, P.C. Biggin, J.P. K. Doye, A.N. Kapanidis, bioRxiv, 2018 [link] DNA-binding proteins utilise different recognition mechanisms to locate their DNA targets. Some proteins recognise … Continue reading

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Accepted: Precision and accuracy of single-molecule FRET measurements – a worldwide benchmark study

B. Hellenkamp, S. Schmid, O. Doroshenko, O. Opanasyuk, R. Kühnemuth, S. Rezaei Adariani, A. Barth, V. Birkedal, M.E. Bowen, H. Chen, T. Cordes, T. Eilert, C. Fijen, M. Götz, G. Gouridis, E. Gratton, T. Ha, C.A. Hanke, A. Hartmann, J. … Continue reading

Posted in accepted, open access, pre-print

Pre-print: Simple nanofluidic devices for high-throughput, non-equilibrium studies at the single-molecule level

C. Fijen, M. Fontana, S.G. Lemay, K. Mathwig, J. Hohlbein, bioRxiv, 2017, [link] Single-molecule detection schemes offer powerful means to overcome static and dynamic heterogeneity inherent to complex samples. Probing chemical and biological interactions and reactions with high throughput and … Continue reading

Posted in open access, pre-print