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- Pre-print: DNA polymerase β fingers movement revealed by single-molecule FRET suggests a partially closed conformation as a fidelity checkpoint
- News: Ph.D. position available!
- News: Welcome to Meike Kronenberg and farewell to Carel Fijen
- News: Welcome to Andreas Hentrich and Hans Dekker…
- Pre-print: Substrate conformational dynamics drive structure-specific recognition of gapped DNA by DNA polymerase
Author Archives: JH
Pre-print: DNA polymerase β fingers movement revealed by single-molecule FRET suggests a partially closed conformation as a fidelity checkpoint
C. Fijen, M. Mahmoud, R. Kaup, J. Towle-Weicksel, J. Sweasy, and J. Hohlbein, bioRxiv, 2018 [link] The eukaryotic DNA polymerase β plays an important role in cellular DNA repair as it fills gaps in single nucleotide gapped DNA that result … Continue reading
The lab has a Ph.D. position titled “Super-resolution microscopy in foods” available! Click [here] for more details and to apply.
Meike joined the group for her BSc thesis and will work on DNA polymerase beta. Carel successfully defended his PhD thesis in March and decided to continue working on DNA polymerase beta by joining the Sweasy lab at Yale as … Continue reading
…who joined the group for an 6 week internship (Andreas) and a short capita selecta (Hans). Andreas will try unifying some fragmented software packages for in vivo single particle tracking. Hans will push the limits of our ultrafast pSMLM algorithm … Continue reading
Pre-print: Substrate conformational dynamics drive structure-specific recognition of gapped DNA by DNA polymerase
T.D. Craggs, M. Sustarsic, A. Plochowietz, M. Mosayebi, H. Kaju, A. Cuthbert, J. Hohlbein, L. Domicevica, P.C. Biggin, J.P. K. Doye, A.N. Kapanidis, bioRxiv, 2018 [link] DNA-binding proteins utilise different recognition mechanisms to locate their DNA targets. Some proteins recognise … Continue reading
B. Hellenkamp, S. Schmid, O. Doroshenko, O. Opanasyuk, R. Kühnemuth, S. Rezaei Adariani, A. Barth, V. Birkedal, M.E. Bowen, H. Chen, T. Cordes, T. Eilert, C. Fijen, M. Götz, G. Gouridis, E. Gratton, T. Ha, C.A. Hanke, A. Hartmann, J. … Continue reading
Good news! The proposal “LocalBioFood: Localisation of bio-macromolecules in food matrices” submitted by Ilja Voets (TU/e) and our lab has been granted by the NWO innovation fund for chemistry [link]. Within the project, the three appointed PhD students will image different components … Continue reading