Introducing miCube V0.1: Rethinking modular fluorescence microscopy

Update: Follow the link or Twitter (#miCube) for the lastest information.

Fluorescence microscopy is an extremely powerful and versatile technique contributing to many areas of the life sciences. Especially variants featuring the ability to monitor single-molecule fluorescence, however, require sophisticated instrumentation that is either very expensive when bought commercially (>> 100 kEuro) or demands extensive expertise in optics and engineering.

Here we present an open and modular hardware framework aiming for

  • cost effectiveness: build your own starting at 20k Euro (~100 kEuro for state of the art capabilities)
  • modularity: all parts can be accessed and replaced by the user
  • simplicity: set up the microscope in a few hours without prior knowledge
  • customizability: confocal or widefield/TIRF microscopy,…
  • openness: part lists and drawings will be made available
  • stability and throughput: minimizing drift and utilise well plate scanners

Interested? Drop me a line. We are currently working together with several academic labs to bring their ideas to life and develop the miCube concept further.


For a similar concept, please also visit

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