Good news! Our proposal “Nanofluidic devices for high-throughput single-molecule fluorescence detection (Nanofluidic-SMFD)” has been granted by the European Commission (FP7-PEOPLE-2013-CIG, #630992). The proposed work aims at utilising nanofluidic devices to overcome current limitations in single-molecule-fluorescence detection. Specifically, we are hoping to monitor enzymatic reactions such as DNA polymerisation in real time without immobilising any of the involved molecules to a surface as it is currently necessary. For this project, we will continue our collaboration with Klaus Mathwig (www.kmathwig.com).
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- News: Welcome to Andreas Hentrich and Hans Dekker…
- Pre-print: Substrate conformational dynamics drive structure-specific recognition of gapped DNA by DNA polymerase
- Pre-print: Precision and accuracy of single-molecule FRET measurements – a worldwide benchmark study
- News: TA proposal awarded
- Published: Phasor based single-molecule localization microscopy in 3D (pSMLM-3D): an algorithm for MHz localization rates using standard CPUs